Defining Immune Responses in COVID-19 to Understand Susceptibility and Target Treatments

Evaluating southern pigtail macaques as an immunological model for human antibody responses

VP Zoest, WS Lee, R Esterbauer, HX Tan, JA Juno, AK Wheatley

2026-12-01

Antibody specificity is primarily derived from immunoglobulin (Ig) genes, which exhibit extensive genetic polymorphism both within..

Mucosal vaccination against SARS-CoV-2 using recombinant influenza viruses delivering self-assembling nanoparticles

D Pilapitiya, WS Lee, MN Vu, A Kelly, RH Webster, M Koutsakos, SJ Kent, JA Juno, HX Tan, AK Wheatley

2025-02-06

Recombinant influenza viruses are promising vectors that can bolster antibody and resident lymphocyte responses within mucosal sit..

Predicting COVID-19 booster immunogenicity against future SARS-CoV-2 variants and the benefits of vaccine updates

D Cromer, A Reynaldi, A Mitchell, TE Schlub, JA Juno, AK Wheatley, SJ Kent, DS Khoury, MP Davenport

2024-12-01

The ongoing evolution of the SARS-CoV-2 virus has led to a move to update vaccine antigens in 2022 and 2023. These updated antigen..

Predicting vaccine effectiveness against severe COVID-19 over time and against variants: a meta-analysis

D Cromer, M Steain, A Reynaldi, TE Schlub, SR Khan, SC Sasson, SJ Kent, DS Khoury, MP Davenport

2023-12-01

Vaccine protection from symptomatic SARS-CoV-2 infection has been shown to be strongly correlated with neutralising antibody titre..

Broad spectrum SARS-CoV-2-specific immunity in hospitalized First Nations peoples recovering from COVID-19

W Zhang, EB Clemens, L Kedzierski, BY Chua, M Mayo, C Lonzi, A Hinchcliff, V Rigas, BF Middleton, P Binks, LC Rowntree, LF Allen, HX Tan, J Petersen, P Chaurasia, F Krammer, AK Wheatley, SJ Kent, J Rossjohn, A Miller

2023-11-01

Indigenous peoples globally are at increased risk of COVID-19-associated morbidity and mortality. However, data that describe immu..

Mucosal antibody responses following Vaxzevria vaccination

KJ Selva, P Ramanathan, ER Haycroft, CW Tan, LF Wang, LE Downie, SK Davis, RA Purcell, HE Kent, JA Juno, AK Wheatley, MP Davenport, SJ Kent, AW Chung

2023-11-01

Mucosal antibodies play a key role in protection against breakthrough COVID-19 infections and emerging viral variants. Intramuscul..

Preexisting immunity restricts mucosal antibody recognition of SARS-CoV-2 and Fc profiles during breakthrough infections

Kevin J Selva, Pradhipa Ramanathan, Ebene R Haycroft, Arnold Reynaldi, Deborah Cromer, Chee Wah Tan, Lin-Fa Wang, Bruce D Wines, P Mark Hogarth, Laura E Downie, Samantha K Davis, Ruth A Purcell, Helen E Kent, Jennifer A Juno, Adam K Wheatley, Miles P Davenport, Stephen J Kent, Amy W Chung

2023-09-22

Understanding mucosal antibody responses from SARS-CoV-2 infection and/or vaccination is crucial to develop strategies for longer ..

Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection

WS Lee, HX Tan, A Reynaldi, R Esterbauer, M Koutsakos, J Nguyen, T Amarasena, HE Kent, A Aggarwal, SG Turville, G Taiaroa, P Kinsella, KC Liew, T Tran, DA Williamson, D Cromer, MP Davenport, SJ Kent, JA Juno, DS Khoury

2023-07-01

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection of vaccinated individuals is increasingly comm..

SARS-CoV-2 breakthrough infection induces rapid memory and de novo T cell responses

M Koutsakos, A Reynaldi, WS Lee, J Nguyen, T Amarasena, G Taiaroa, P Kinsella, KC Liew, T Tran, HE Kent, HX Tan, LC Rowntree, THO Nguyen, PG Thomas, K Kedzierska, J Petersen, J Rossjohn, DA Williamson, D Khoury, MP Davenport

2023-04-11

Although the protective role of neutralizing antibodies against COVID-19 is well established, questions remain about the relative ..

Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals

A von Borstel, THO Nguyen, LC Rowntree, TM Ashhurst, LF Allen, LJ Howson, NE Holmes, OC Smibert, JA Trubiano, CL Gordon, AC Cheng, SJ Kent, J Rossjohn, K Kedzierska, MS Davey

2023-04-01

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe coronavirus disease 2019 (COVID-19) in a smal..

Robust SARS-CoV- 2 antibody and T cell immunity following three COVID-19 vaccine doses in inflammatory bowel disease patients receiving anti-TNF or alternative treatments

E Zhang, THO Nguyen, LF Allen, L Kedzierski, LC Rowntree, SY Chang, W Zhang, JR Habel, IJ Foo, T Menon, J Mitchell, RW Leong, K Bond, DA Williamson, K Kedzierska, B Christensen

2023-03-06

Predicting the efficacy of variant-modified COVID-19 vaccine boosters

DS Khoury, SS Docken, K Subbarao, SJ Kent, MP Davenport, D Cromer

2023-03-01

Booster vaccination for the prevention of Coronavirus Disease 2019 (COVID-19) is required to overcome loss of protection due to wa..

Prospective comprehensive profiling of immune responses to COVID-19 vaccination in patients on zanubrutinib therapy

Thi HO Nguyen, Chhay Lim, Masa Lasica, Ashley Whitechurch, Surekha Tennakoon, Natalie R Saunders, Lilith F Allen, Louise C Rowntree, Brendon Y Chua, Lukasz Kedzierski, Hyon-Xhi Tan, Adam K Wheatley, Stephen J Kent, Theo Karapanagiotidis, Suellen Nicholson, Deborah A Williamson, Monica A Slavin, Constantine S Tam, Katherine Kedzierska, Benjamin W Teh

2023-02-01

Zanubrutinib-treated and treatment-naïve patients with chronic lymphocytic leukaemia (CLL) or Waldenstrom's macroglobulinaemia wer..

Robust immunity to influenza vaccination in haematopoietic stem cell transplant recipients following reconstitution of humoral and adaptive immunity

W Zhang, LC Rowntree, R Muttucumaru, T Damelang, M Aban, AC Hurt, M Auladell, R Esterbauer, B Wines, M Hogarth, SJ Turner, AK Wheatley, SJ Kent, S Patil, S Avery, O Morrissey, AW Chung, M Koutsakos, THO Nguyen, AC Cheng

2023-01-01

Objectives: Influenza causes significant morbidity and mortality, especially in high-risk populations. Although current vaccinatio..

VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2

M Goncharov, D Bagaev, D Shcherbinin, I Zvyagin, D Bolotin, PG Thomas, AA Minervina, MV Pogorelyy, K Ladell, JE McLaren, DA Price, THO Nguyen, LC Rowntree, EB Clemens, K Kedzierska, G Dolton, CR Rius, A Sewell, J Samir, F Luciani

2022-09-01

The magnitude and timing of recalled immunity after breakthrough infection is shaped by SARS-CoV-2 variants

M Koutsakos, WS Lee, A Reynaldi, HX Tan, G Gare, P Kinsella, KC Liew, G Taiaroa, DA Williamson, HE Kent, E Stadler, D Cromer, DS Khoury, AK Wheatley, JA Juno, MP Davenport, SJ Kent

2022-07-12

Vaccination against SARS-CoV-2 protects from infection and improves clinical outcomes in breakthrough infections, likely reflectin..

Disentangling the relative importance of T cell responses in COVID-19: leading actors or supporting cast?

SJ Kent, DS Khoury, A Reynaldi, JA Juno, AK Wheatley, E Stadler, E John Wherry, J Triccas, SC Sasson, D Cromer, MP Davenport

2022-06-01

The rapid development of multiple vaccines providing strong protection from severe acute respiratory syndrome coronavirus 2 (SARS-..

Are NKT cells a useful predictor of COVID-19 severity?

HF Koay, NA Gherardin, THO Nguyen, W Zhang, JR Habel, R Seneviratna, F James, NE Holmes, OC Smibert, CL Gordon, JA Trubiano, K Kedzierska, DI Godfrey

2022-02-08

Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection

C Phetsouphanh, DR Darley, DB Wilson, A Howe, CML Munier, SK Patel, JA Juno, LM Burrell, SJ Kent, GJ Dore, AD Kelleher, GV Matthews

2022-02-01

A proportion of patients surviving acute coronavirus disease 2019 (COVID-19) infection develop post-acute COVID syndrome (long COV..

SARS-CoV-2-specific CD8 T-cell responses and TCR signatures in the context of a prominent HLA-A*24:02 allomorph

LC Rowntree, J Petersen, JA Juno, P Chaurasia, K Wragg, M Koutsakos, L Hensen, AK Wheatley, SJ Kent, J Rossjohn, K Kedzierska, THO Nguyen

2021-10-01

In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is needed if we are to optimize va..

Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein

P Chaurasia, THO Nguyen, LC Rowntree, JA Juno, AK Wheatley, SJ Kent, K Kedzierska, J Rossjohn, J Petersen

2021-09-01

CD8⁺ T cells play an important role in vaccination and immunity against severe acute respiratory syndrome coronavirus 2..

Influenza, but not SARS-CoV-2, infection induces a rapid interferon response that wanes with age and diminished tissue-resident memory CD8 T cells

THO Nguyen, JL McAuley, Y Kim, MZM Zheng, NA Gherardin, DI Godfrey, DFJ Purcell, LC Sullivan, GP Westall, PC Reading, K Kedzierska, LM Wakim

2021-01-01

Older individuals exhibit a diminished ability to respond to and clear respiratory pathogens and, as such, experience a higher rat..